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KMID : 1040120170030010013
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Evidence and Values in Healthcare
2017 Volume.3 No. 1 p.13 ~ p.18
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An analysis of adverse reactions for weight loss supplements in Korea: Garcinia cambogia extract and Irvingia gabonensis seed extract
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Park Joo-Yeon
Park Ji-Jeong
Seo Seong-Woo
Shim Jung-Im
Shin Chae-Min
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Abstract
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Objectives: The aim of this study is to analyze the adverse effects or reports of adverse reactions involving Garcinia cambogia extract and Irvingia gabonensis seed extract.
Methods: To review the adverse reactions that occurred after taking the supplements, we collected detailed data using the submitted reports of adverse effects and adverse events for the past two years with cooperation from the KCA and MFDS. We then analyzed the adverse effects and adverse reactions based on the symptom information provided. In addition, the analytical methods were established, and the risks and toxicities were analyzed based on consultation from relevant clinical experts.
Results: 3,220 cases of adverse effects of food supplements were reported, of which 243 cases involved Garcinia cambogia extract and 17 cases involved Irvingia gabonensis seed extract. Most of the adverse effects were gastrointestinal or skin-related, and only 21 cases involved the liver/renal/urinary system. Another adverse reactions pertaining to Garcinia cambogia extract intake reported include conjunctivitis, skin problems, fever, vertigo, a low glomerular filtration rate and gastrointestinal disturbance, vomiting, anal and pudendal allergies, facial edema, headache, mood swings, depression, and lethargy.
Conclusion: Analysis of the adverse events could not confirm a causal relationship owing to limited data, but these products should be taken with caution, as there have been reports of systemic skin trouble, abdominal pain, vertigo, skin trouble, vomiting, and edema.
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KEYWORD
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Weight loss, Garcinia cambogia, Irvingia gabonesis, Safety, Adverse effects
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